Is coming soon.
The antigen-binding capacity of nanobodies is similar to conventional antibodies for three reasons. First, the complementarity-determining region 3 (CDR3) of nanobodies is similar or even longer than that of human VH domain (variable domain of heavy immunoglobulin chain). Second, nanobodies can form finger-like structures to recognize cavities or hidden epitopes that are not available to mAbs. Third, nanobodies exhibit excellent stability, hydrophilicity, and water solubility that help maintain their binding affinity across different conditions.
Nanobodies can be used for early and rapid diagnosis of disease, which is essential for detecting some highly pathogenic, infectious and potentially deadly pathogens.