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Nanobody Platform

Nanobody is the variable domain of heavy-chain-only antibody (HcAbs), which is 4 nm in length, 2.5 nm in width, and only 15 kD in molecular weight, due to the lack of the light chains (L) and heavy chain constant domain (CH) compared with conventional monoclonal antibodies (mAbs).
Nanobodies have unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseases.

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Nanobody Screening (Nuclear System)

The customized Nanobody Screening Nuclear System can quickly and efficiently screen and identify nanobodies that function in the nucleus The antigen-binding capacity of nanobodies is similar to conventional antibodies for three reasons. First, the complementarity-determining region 3 (CDR3) of nanobodies is similar to or even longer than that of the human VH domain (variable domain of heavy immunoglobulin chain).


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