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What is Nanobody

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Nanobody is the variable domain of heavy-chain-only antibody (HcAbs) that was first isolated two decades ago from the serum of Camelidae family. The nomenclature of “nanobody” originally adopted by the Belgian company Ablynx® stemmed from its nanometric size, i.e., 4 nm in length, 2.5 nm in width, and only 15 kD in molecular weight, which was attributed to the lack of the light chains (L) and heavy chain constant domain (CH) in contrast to the conventional monoclonal antibodies (mAbs).

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